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Metabolic Map of Fibrotic Skin: Spatial Proteomics in Systemic Sclerosis

Metabolic Map of Fibrotic Skin: Spatial Proteomics in Systemic Sclerosis

Metabolic Phenotyping Unravels Fibroblast Niches Driving Progressive Skin Fibrosis

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Martin Duenas
Jul 23, 2025
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OniX OnPoint Newsletter
OniX OnPoint Newsletter
Metabolic Map of Fibrotic Skin: Spatial Proteomics in Systemic Sclerosis
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Metabolic Phenotyping Unravels Fibroblast Niches Driving Progressive Skin Fibrosis

In a cutting-edge study using spatial proteomics and imaging mass cytometry (IMC), researchers led by V. Devakumar and A.E. Matei from University Hospital Düsseldorf have decoded the previously unrecognized metabolic heterogeneity of skin fibroblasts in systemic sclerosis (SSc).

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